Metabolic syndrome and risk of cancer mortality in men

Eur J Cancer. 2009 Jul;45(10):1831-8. doi: 10.1016/j.ejca.2009.01.031. Epub 2009 Feb 26.


Background: Metabolic syndrome (MetS) has been linked with an increased risk of developing cancer; however, the association between MetS and cancer mortality remains less clear. Little research has focused on pre-cancer risk factors that may affect the outcome of treatment. The purpose of this study was to examine the association between MetS and all-cancer mortality in men.

Methods: The participants included 33,230 men aged 20-88 years who were enrolled in the Aerobics Centre Longitudinal Study and who were free of known cancer at the baseline.

Results: At baseline 28% of all the participants had MetS. During an average of 14 years follow-up, there were a total of 685 deaths due to cancer. MetS at baseline was associated with a 56% greater age-adjusted risk in cancer mortality.

Conclusion: These data show that MetS is associated with an increased risk of all-cause cancer mortality in men. Based on these findings, it is evident that successful interventions should be identified to attenuate the negative effects of MetS.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cholesterol, HDL / blood
  • Epidemiologic Methods
  • Humans
  • Hyperglycemia / complications
  • Hyperglycemia / mortality
  • Male
  • Metabolic Syndrome / blood
  • Metabolic Syndrome / complications*
  • Metabolic Syndrome / mortality
  • Middle Aged
  • Neoplasms / blood
  • Neoplasms / etiology
  • Neoplasms / mortality*
  • Obesity / complications
  • Obesity / mortality
  • Texas / epidemiology
  • Triglycerides / blood
  • Young Adult


  • Cholesterol, HDL
  • Triglycerides