Closing the feedback loop: how cells "count" telomere-bound proteins

Mol Cell. 2009 Feb 27;33(4):413-4. doi: 10.1016/j.molcel.2009.02.001.

Abstract

Telomere length homeostasis is thought to occur via a "protein-counting" mechanism whereby high numbers of telomere-bound proteins inhibit telomerase activity. In a recent issue of Molecular Cell, Hirano et al. (2009) delineate the molecular interactions that underlie the budding yeast protein-counting machinery.

Publication types

  • Comment

MeSH terms

  • DNA, Fungal / metabolism
  • Fungal Proteins / metabolism
  • Models, Biological
  • Telomerase / metabolism
  • Telomere / metabolism*
  • Telomere-Binding Proteins / metabolism*

Substances

  • DNA, Fungal
  • Fungal Proteins
  • Telomere-Binding Proteins
  • Telomerase