Posterior capsule opacification and neodymium:YAG laser capsulotomy rates with a round-edged silicone and a sharp-edged hydrophobic acrylic intraocular lens 10 years after surgery

J Cataract Refract Surg. 2009 Mar;35(3):459-65. doi: 10.1016/j.jcrs.2008.11.044.


Purpose: To compare posterior capsule opacification (PCO) and neodymium:YAG (Nd:YAG) laser capsulotomy rates 10 years after surgery between two 3-piece intraocular lenses (IOLs): a silicone IOL with round optic edges and a hydrophobic acrylic IOL with sharp optic edges.

Setting: Department of Ophthalmology, Medical University of Vienna, Vienna General Hospital, Vienna, Austria.

Methods: Patients having had cataract surgery and implantation of at least 1 study IOL by the same surgeon between 1994 and 1999 were retrospectively examined. The number of Nd:YAG laser capsulotomies performed was noted. The PCO intensity was assessed using digital retroilluminated photographs and Automated Quantification of After-Cataract (AQUA) software. The AQUA scores in eyes with Nd:YAG capsulotomy were estimated with a multiple-imputation procedure. Anterior capsule opacification (ACO) and fibrotic PCO were graded subjectively at the slitlamp.

Results: The study evaluated 143 eyes (98 patients). Eight (18%) of 44 eyes with a silicone IOL and 41 (42%) of 99 eyes with an acrylic IOL had Nd:YAG capsulotomy after 10 years (P = .007). The AQUA scores were lower with the silicone IOLs. The median difference in AQUA scores was significantly different after missing values of the Nd:YAG capsulotomies were imputed. There was no difference in ACO. There was more fibrotic PCO with round-edged silicone IOLs than with sharp-edged acrylic IOLs.

Conclusions: Ten years after surgery, acrylic IOLs seemed to lose their PCO preventive effect, despite their sharp optic edges. The increasingly longer life expectancy and earlier cataract surgery mandate reconsideration of preferences regarding optic materials and design elements of IOLs.

Publication types

  • Comparative Study

MeSH terms

  • Acrylic Resins*
  • Aged
  • Cataract / epidemiology*
  • Cataract / etiology
  • Cataract / therapy
  • Cross-Sectional Studies
  • Female
  • Follow-Up Studies
  • Humans
  • Laser Therapy / statistics & numerical data*
  • Lasers, Solid-State / therapeutic use*
  • Lens Capsule, Crystalline / pathology*
  • Lens Capsule, Crystalline / surgery
  • Lens Implantation, Intraocular
  • Lenses, Intraocular*
  • Male
  • Middle Aged
  • Postoperative Complications*
  • Prosthesis Design
  • Retrospective Studies
  • Silicone Elastomers*
  • Tomography, Optical Coherence
  • Treatment Outcome


  • Acrylic Resins
  • Silicone Elastomers