Exploring the therapeutic role of creatine supplementation

Amino Acids. 2010 Jan;38(1):31-44. doi: 10.1007/s00726-009-0263-6. Epub 2009 Mar 1.


Creatine (Cr) plays a central role in energy provision through a reaction catalyzed by phosphorylcreatine kinase. Furthermore, this amine enhances both gene expression and satellite cell activation involved in hypertrophic response. Recent findings have indicated that Cr supplementation has a therapeutic role in several diseases characterized by atrophic conditions, weakness, and metabolic disturbances (i.e., in the muscle, bone, lung, and brain). Accordingly, there has been an evidence indicating that Cr supplementation is capable of attenuating the degenerative state in some muscle disorders (i.e., Duchenne and inflammatory myopathies), central nervous diseases (i.e., Parkinson's, Huntington's, and Alzheimer's), and bone and metabolic disturbances (i.e., osteoporosis and type II diabetes). In light of this, Cr supplementation could be used as a therapeutic tool for the elderly. The aim of this review is to summarize the main studies conducted in this field and to highlight the scientific and clinical perspectives of this promising therapeutic supplement.

Publication types

  • Review

MeSH terms

  • Central Nervous System Diseases / drug therapy*
  • Central Nervous System Diseases / metabolism
  • Creatine / metabolism
  • Creatine / therapeutic use*
  • Dietary Supplements*
  • Humans
  • Metabolic Diseases / drug therapy*
  • Metabolic Diseases / metabolism
  • Muscular Diseases / drug therapy*
  • Muscular Diseases / metabolism
  • Randomized Controlled Trials as Topic


  • Creatine