Zopiclone in the treatment of sleep abnormalities in fibromyalgia

Scand J Rheumatol. 1991;20(4):288-93. doi: 10.3109/03009749109096802.


The clinical and polysomnographical effects of zopiclone were evaluated in 41 patients with fibromyalgia in a double blind controlled study. A significant improvement was observed regarding tiredness during the day and subjective sleep complaints, but no effects on pain or stiffness were observed. The sleep structure remained unchanged during treatment. Zopiclone seems to be of value in treating the sleep complaints in patients with fibromyalgia.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Azabicyclo Compounds
  • Female
  • Fibromyalgia / drug therapy*
  • Fibromyalgia / physiopathology
  • Humans
  • Hypnotics and Sedatives / therapeutic use
  • Middle Aged
  • Piperazines / therapeutic use*
  • Sleep Wake Disorders / drug therapy
  • Sleep Wake Disorders / etiology*
  • Sleep Wake Disorders / physiopathology
  • Sleep, REM / drug effects


  • Azabicyclo Compounds
  • Hypnotics and Sedatives
  • Piperazines
  • zopiclone