A Notch updated

J Cell Biol. 2009 Mar 9;184(5):621-9. doi: 10.1083/jcb.200811141. Epub 2009 Mar 2.


Cell-cell signaling mediated by the Notch receptor is iteratively involved in numerous developmental contexts, and its dysregulation has been associated with inherited genetic disorders and cancers. The core components of the signaling pathway have been identified for some time, but the study of the modulation of the pathway in different cellular contexts has revealed many layers of regulation. These include complex sugar modifications in the extracellular domain as well as transit of Notch through defined cellular compartments, including specific endosomes.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Membrane / chemistry
  • Cell Membrane / metabolism
  • Drosophila Proteins / chemistry*
  • Drosophila Proteins / metabolism*
  • Endocytosis / physiology*
  • Glycosylation
  • Humans
  • Ligands
  • Peptide Hydrolases / metabolism
  • Protein Structure, Tertiary / physiology
  • Receptors, Notch / chemistry*
  • Receptors, Notch / metabolism*
  • Signal Transduction / physiology*


  • Drosophila Proteins
  • Ligands
  • N protein, Drosophila
  • Receptors, Notch
  • Peptide Hydrolases