Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2009 Mar;10(1):81-3.
doi: 10.4142/jvs.2009.10.1.81.

Multilobular tumour of the caudal cranium causing severe cerebral and cerebellar compression in a dog

Affiliations
Case Reports

Multilobular tumour of the caudal cranium causing severe cerebral and cerebellar compression in a dog

Vassilios Psychas et al. J Vet Sci. 2009 Mar.

Abstract

Multilobular tumour of bone (MTB) is an uncommon tumour and is usually located in the skull. A 13-year-old mixed breed dog was presented with a two-week history of progressively worsening vestibular dysfunction and cognitive abnormalities; it appeared demented and showed asymmetric ataxia and hypermetria of all limbs. The owner opted to have the animal euthanised. Necropsy revealed a large mass occupying the right occipital, parietal and temporal bones, severely compressing the cerebellum and the right occipital lobe. Histologically, it was characterised by the presence of multiple lobules containing osteoid or cartilage and separated by fibrous septae, features typical of MTB. Lung metastases were evident. To our knowledge, this is the first report of an MTB causing both severe cerebral and cerebellar compression and the second detailed report of an MTB of the occipital bone. MTB should be included in the differential diagnosis of bone tumours as well as in cases with central vestibular disease.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Note the presence of a large, spherical, whitish to yellow, well-circumscribed mass occupying the right occipital, parietal and temporal bones (A, B) and protruding from the right occipital bone (A). The mass expanded into the cranial cavity (B) and severely compressed the cerebellum and the right occipital lobe (encircled C and D before and after the removal of the meninges, respectively).
Fig. 2
Fig. 2
Primary (A, B, C) and secondary (D) multilobular tumour of bone. Note the dominant presence of multiple lobules containing osteoid tissue (C: left) or cartilage (C: right) and separated by fibrous septa, a feature typical of the multilobular tumour of bone. In marginal areas (C), the lobules were not as well formed and the tumour cells were in places arranged in sheets, features denoting a high-grade malignancy. (D) Metastatic focus in the lungs retaining the multilobular pattern, albeit forming lobules that were smaller and of more uniform size. H&E stain, (A) decalcified section. Scale bars = A: 260 µm, B: 104 µm, C: 52 µm, D: 260 µm.

Similar articles

Cited by

References

    1. Banks TA, Straw RC. Multilobular osteochondrosarcoma of the hard palate in a dog. Aust Vet J. 2004;82:409–412. - PubMed
    1. Dernell WS, Straw RC, Cooper MF, Powers BE, LaRue SM, Withrow SJ. Multilobular osteochondrosarcoma in 39 dogs: 1979-1993. J Am Anim Hosp Assoc. 1998;34:11–18. - PubMed
    1. Hanley CS, Gieger T, Frank P. What is your diagnosis? Multilobular osteoma (MLO) J Am Vet Med Assoc. 2004;225:1665–1666. - PubMed
    1. Hathcock JT, Newton JC. Computed tomographic characteristics of multilobular tumor of bone involving the cranium in 7 dogs and zygomatic arch in 2 dogs. Vet Radiol Ultrasound. 2000;41:214–217. - PubMed
    1. Jacobson SA. The Comparative Pathology of the Tumors of Bone. Springfield: Thomas; 1971. pp. 102–109.

Publication types