Botulinum A toxin (Oculinum) in ophthalmology

Surv Ophthalmol. 1991 Jul-Aug;36(1):28-46. doi: 10.1016/0039-6257(91)90207-v.


Botulinum A toxin has been used to treat strabismus and a variety of spasmodic neuromuscular diseases. Botulinum toxin treatment of strabismus is not as definitive and stable as the traditional surgical approach, but it has been found most useful in postoperative overcorrection, small deviations, sensory deviations, and acute sixth nerve palsy. This toxin has been effective in the treatment of essential blepharospasm and hemifacial spasm, for which it produces temporary relief of symptoms. In addition, this treatment has been applied to lower lid entropion, myokymia, aberrant regeneration of the seventh nerve, lid retraction, corneal exposure, nystagmus, spasmodic torticollis, and adductor spastic dysphonia.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Blepharospasm / therapy
  • Botulinum Toxins / adverse effects
  • Botulinum Toxins / pharmacology
  • Botulinum Toxins / therapeutic use*
  • Corneal Diseases / therapy
  • Eye Diseases / therapy*
  • Facial Muscles
  • Humans
  • Nystagmus, Pathologic / therapy
  • Spasm / therapy
  • Strabismus / therapy*
  • Torticollis / therapy


  • Botulinum Toxins