mTOR and the control of whole body metabolism

Curr Opin Cell Biol. 2009 Apr;21(2):209-18. doi: 10.1016/j.ceb.2009.01.024. Epub 2009 Mar 2.

Abstract

Mammalian Target of Rapamycin (mTOR) is a highly conserved protein kinase that functions as part of two distinct multiprotein complexes to regulate growth and metabolism. This review describes the most important recent advances in the mTOR signaling field. In addition, we provide an overview on the functions of mTOR in different organs, with a special focus on the role of mTOR in whole body energy metabolism.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Energy Metabolism*
  • Humans
  • Mechanistic Target of Rapamycin Complex 1
  • Multiprotein Complexes
  • Phenotype
  • Protein Kinases / metabolism*
  • Proteins
  • Signal Transduction / physiology*
  • TOR Serine-Threonine Kinases
  • Transcription Factors / metabolism

Substances

  • CRTC2 protein, human
  • Multiprotein Complexes
  • Proteins
  • Transcription Factors
  • Protein Kinases
  • MTOR protein, human
  • TOR Serine-Threonine Kinases
  • Mechanistic Target of Rapamycin Complex 1