Effects of mobile phone radiofrequency on the structure and function of the normal human hemoglobin

Int J Biol Macromol. 2009 Apr 1;44(3):278-85. doi: 10.1016/j.ijbiomac.2009.01.001.


Widespread use of mobile phones has increased the human exposure to electromagnetic fields (EMFs). It is required to investigate the effect of EMFs on the biological systems. In this paper the effect of mobile phone RF (910MHz and 940 MHz) on structure and function of HbA was investigated. Oxygen affinity was measured by sodium dithionite with UV-vis spectrophotometer. Structural changes were studied by circular dichroism and fluorescence spectroscopy. The results indicated that mobile phone EMFs altered oxygen affinity and tertiary structure of HbA. Furthermore, the decrease of oxygen affinity of HbA corresponded to the EMFs intensity and time of exposure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anilino Naphthalenesulfonates / chemistry
  • Buffers
  • Cell Phone*
  • Circular Dichroism
  • Fluorescence
  • Hemoglobins / chemistry*
  • Hemoglobins / metabolism*
  • Hemoglobins / radiation effects
  • Humans
  • Hydrogen-Ion Concentration
  • Oxygen / metabolism
  • Protein Denaturation
  • Protein Folding
  • Protein Structure, Quaternary
  • Radio Waves*
  • Temperature
  • Time Factors


  • Anilino Naphthalenesulfonates
  • Buffers
  • Hemoglobins
  • 1-anilino-8-naphthalenesulfonate
  • Oxygen