Diacylglycerol kinases as sources of phosphatidic acid

Biochim Biophys Acta. 2009 Sep;1791(9):942-8. doi: 10.1016/j.bbalip.2009.02.010. Epub 2009 Mar 2.


There are ten mammalian diacylglycerol kinases (DGKs) whose primary role is to terminate diacylglycerol (DAG) signaling. However, it is becoming increasingly apparent that DGKs also influence signaling events through their product, phosphatidic acid (PA). They do so in some cases by associating with proteins and then modifying their activity by generating PA. In other cases, DGKs broadly regulate signaling events by virtue of their ability to provide PA for the synthesis of phosphatidylinositols (PtdIns).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Diacylglycerol Kinase / chemistry
  • Diacylglycerol Kinase / metabolism*
  • Humans
  • Models, Biological
  • Phosphatidic Acids / metabolism*
  • Phosphatidylinositols / metabolism
  • Protein Binding
  • Signal Transduction


  • Phosphatidic Acids
  • Phosphatidylinositols
  • Diacylglycerol Kinase