Control of Salmonella pathogenicity island-2 gene expression

Curr Opin Microbiol. 2009 Apr;12(2):199-204. doi: 10.1016/j.mib.2009.01.004. Epub 2009 Mar 4.

Abstract

The Salmonella Pathogenicity Island-2 (i.e. SPI-2) encodes a unique type III secretion system that delivers effector proteins from the Salmonella-containing vacuole (SCV) into the host cell. The SPI-2 locus also encodes translocated effectors as well as a two-component system - termed SpiR/SsrB - that is essential for the expression of SPI-2 genes. Transcription of the horizontally acquired SPI-2 genes requires the ancestral nucleoid-associated proteins (i.e. NAPs) IHF and Fis, the regulatory protein SlyA, and the two-component systems PhoP/PhoQ and OmpR/EnvZ, as well as the DNA binding protein HilD encoded in a different pathogenicity island. Some of these positive SPI-2 regulators act to antagonize the robust silencing promoted by the NAPs H-NS, Hha, and YdgT.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Gene Expression Regulation, Bacterial*
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Transcription Factors / metabolism*

Substances

  • Bacterial Proteins
  • Membrane Proteins
  • SPI-2 protein, Salmonella
  • Transcription Factors