Abstract
New spirocyclic and bicyclic hemiacetals, isariotins E (1) and F (2), together with TK-57-164A (3) were isolated from the entomopathogenic fungus Isaria tenuipes BCC 12625. The absolute configuration of 3 was addressed by application of the modified Mosher's method. Isariotin F (2) exhibited activity against the malaria parasite Plasmodium falciparum K1 with an IC(50) value of 5.1 microM and cytotoxic activities against cancer cell lines (KB, BC, and NCI-H187) and nonmalignant (Vero) cells with respective IC(50) values of 15.8, 2.4, 1.6, and 2.9 microM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimalarials / chemistry
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Antimalarials / isolation & purification*
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Antimalarials / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Antitubercular Agents / chemistry
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Antitubercular Agents / isolation & purification*
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Antitubercular Agents / pharmacology
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Bridged Bicyclo Compounds, Heterocyclic / chemistry
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Bridged Bicyclo Compounds, Heterocyclic / isolation & purification*
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Bridged Bicyclo Compounds, Heterocyclic / pharmacology
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Candida albicans / drug effects
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Chlorocebus aethiops
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Drug Screening Assays, Antitumor
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Epoxy Compounds / chemistry
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Epoxy Compounds / isolation & purification*
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Heterocyclic Compounds, Bridged-Ring / chemistry
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Heterocyclic Compounds, Bridged-Ring / isolation & purification*
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Humans
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Hypocreales / chemistry*
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Inhibitory Concentration 50
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Molecular Structure
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Mycobacterium tuberculosis / drug effects
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Parasitic Sensitivity Tests
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Plasmodium falciparum / drug effects*
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Spiro Compounds / chemistry
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Spiro Compounds / isolation & purification*
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Spiro Compounds / pharmacology
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Thailand
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Vero Cells
Substances
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Antimalarials
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Antineoplastic Agents
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Antitubercular Agents
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Bridged Bicyclo Compounds, Heterocyclic
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Epoxy Compounds
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Heterocyclic Compounds, Bridged-Ring
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Spiro Compounds
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TK-57-164A
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isariotin E
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isariotin F