New developments in immunosuppressive therapy for heart transplantation

Expert Opin Emerg Drugs. 2009 Mar;14(1):1-21. doi: 10.1517/14728210902791605.


Background: Heart transplantation is a well-established therapeutic option for many patients with end-stage heart disease. A major challenge in heart transplantation today is providing effective immunosuppression to prevent graft rejection while minimizing the many adverse effects of currently available therapies.

Objective: To systematically review current immunosuppressive treatment strategies after heart transplantation and to review emerging drugs in various stages of development.

Methods: A comprehensive literature review was performed using the online PubMed and Pharmaprojects databases.

Results/conclusions: This article gives an overview of the immunosuppressive agents in current use, with a detailed review of emerging drugs with novel therapeutic targets.

Publication types

  • Review

MeSH terms

  • Animals
  • Clinical Trials as Topic
  • Drug Delivery Systems*
  • Drug Design
  • Graft Rejection / prevention & control
  • Heart Diseases / surgery
  • Heart Transplantation*
  • Humans
  • Immunosuppressive Agents / adverse effects
  • Immunosuppressive Agents / pharmacology
  • Immunosuppressive Agents / therapeutic use*


  • Immunosuppressive Agents