Decoding the hemogenic endothelium in mammals

Cell Stem Cell. 2009 Mar 6;4(3):189-90. doi: 10.1016/j.stem.2009.02.006.


A collection of recent Nature papers examines the relationship between endothelial precursors and hematopoietic cells. Two of these studies (Eilken et al., 2009; Lancrin et al., 2009) use time-lapse imaging with live markers and genetic analysis of differentiating ESCs to reveal that even non-aortic-derived endothelial cells are hemogenic.

MeSH terms

  • Animals
  • Blood Vessels / physiology*
  • Cell Differentiation / physiology*
  • Endothelium, Vascular / physiology*
  • Hemangioblasts / physiology*
  • Hematopoietic Stem Cells / physiology*
  • Mice