Ocular complications following I-125 brachytherapy for choroidal melanoma

Eye (Lond). 2009 Jun;23(6):1254-68. doi: 10.1038/eye.2009.43. Epub 2009 Mar 6.


Uveal melanoma has traditionally been treated with enucleation, plaque brachytherapy, or external beam radiation. Following the results of the multicenter Collaborative Ocular Melanoma Study (COMS), which established no significant difference in mortality rates between enucleation and brachytherapy, plaque brachytherapy has become the favoured modality given its potential for preservation of vision and the eye. Among the radioisotopes that have been used, iodine-125 (I-125) has become the increasingly popular choice in the United States. However, I-125 brachytherapy is associated with complications, including keratitis, iris neovascularization, neovascular glaucoma, radiation retinopathy, and optic neuropathy. The purpose of this review is to discuss the pathogenesis, clinical presentation, and management of complications related to I-125 plaque brachytherapy for choroidal melanoma.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Brachytherapy / adverse effects*
  • Choroid Neoplasms / radiotherapy*
  • Eye Diseases / etiology*
  • Eye Diseases / therapy
  • Humans
  • Iodine Radioisotopes / adverse effects*
  • Iodine Radioisotopes / therapeutic use
  • Melanoma / radiotherapy*
  • Visual Acuity


  • Iodine Radioisotopes