Population genetic models of duplicated genes

Genetica. 2009 Sep;137(1):19-37. doi: 10.1007/s10709-009-9355-1. Epub 2009 Mar 6.


Various population genetic models of duplicated genes are introduced. The problems covered in this review include the fixation process of a duplicated copy, copy number polymorphism, the fates of duplicated genes and single nucleotide polymorphism in duplicated genes. Because of increasing evidence for concerted evolution by gene conversion, this review introduces recently developed gene conversion models. In the first half, models assuming independent evolution of duplicated genes are introduced, and then the effect of gene conversion is considered in the second half.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Base Sequence
  • Evolution, Molecular
  • Gene Conversion / genetics
  • Gene Dosage / genetics
  • Gene Duplication
  • Genes, Duplicate / genetics*
  • Humans
  • Models, Genetic*
  • Polymorphism, Genetic