Endothelial Cells Form a Phalanx to Block Tumor Metastasis

Cell. 2009 Mar 6;136(5):810-2. doi: 10.1016/j.cell.2009.02.021.

Abstract

Tumor blood vessels deliver oxygen poorly, thereby contributing to tumor hypoxia and upregulation of proangiogenic cytokines in an escalating feedback loop. Mazzone et al. (2009) now show that reducing the amount of a protein involved in endothelial oxygen sensing leads to changes in endothelial cell shape that interrupt this feedback loop and reduce tumor metastasis.

Publication types

  • Editorial
  • Comment

MeSH terms

  • Animals
  • Blood Vessels / cytology*
  • Cell Shape
  • Cytokines / metabolism
  • Endothelial Cells / cytology
  • Endothelial Cells / metabolism*
  • Humans
  • Hypoxia / metabolism*
  • Neoplasms / blood supply*
  • Neoplasms / metabolism*
  • Oxygen / metabolism
  • Procollagen-Proline Dioxygenase / metabolism

Substances

  • Cytokines
  • Procollagen-Proline Dioxygenase
  • Oxygen