PPTR-1 counterAkts insulin signaling

Cell. 2009 Mar 6;136(5):816-8. doi: 10.1016/j.cell.2009.02.029.


The serine/threonine kinase Akt is a focal point in signaling pathways that control cell tumorigenesis and insulin resistance. In this issue, Padmanabhan et al. (2009) identify a phosphatase regulatory subunit PPTR-1 that regulates the insulin/insulin-like growth factor 1 pathway by counteracting Akt activity in worms and mammalian cells.

Publication types

  • Comment
  • Editorial

MeSH terms

  • Animals
  • Caenorhabditis elegans / growth & development
  • Caenorhabditis elegans / metabolism*
  • Caenorhabditis elegans Proteins / metabolism*
  • Insulin / metabolism*
  • Proto-Oncogene Proteins c-akt / metabolism*
  • Signal Transduction*


  • Caenorhabditis elegans Proteins
  • Insulin
  • pptr-1 protein, C elegans
  • Proto-Oncogene Proteins c-akt