Abstract
Topical microbicides offer women the opportunity to protect themselves from sexual HIV transmission under their own control. A series of poly[styrene-alt-(maleic anhydride)] derivatives were prepared by amidation or hydrolysis of the anhydride moiety. The derivatives were shown to be of low cell toxicity and effectively inhibited HIV-1 infections in an in vitro cellular model. Poly[styrene-alt-(maleic acid, sodium salt)] was the most potent inhibitor, being 100-fold more potent than dextran sulfate suggesting its potential application as a new class of polyanionic microbicides.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / chemical synthesis*
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Anti-HIV Agents / pharmacology
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Anti-HIV Agents / toxicity
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Anti-Infective Agents, Local / chemical synthesis*
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Anti-Infective Agents, Local / pharmacology
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Anti-Infective Agents, Local / toxicity
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Cell Line
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HIV Infections / prevention & control
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HeLa Cells
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Humans
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Maleates / chemical synthesis*
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Maleates / pharmacology
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Maleates / toxicity
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Polystyrenes / chemical synthesis*
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Polystyrenes / pharmacology
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Polystyrenes / toxicity
Substances
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Anti-HIV Agents
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Anti-Infective Agents, Local
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Maleates
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Polystyrenes
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poly(styrene-alt-maleic anhydride)