Responses of Pseudomonas to small toxic molecules by a mosaic of domains

Curr Opin Microbiol. 2009 Apr;12(2):215-20. doi: 10.1016/j.mib.2009.02.001. Epub 2009 Mar 9.


Transcriptional responses of microorganisms to environmental perturbations are broad and complex, and often involve regulatory cascades in which an interplay of regulatory factors trigger a specific expression program. Here, we describe how Pseudomonas responds to challenges from toxic chemicals, for which they use a dedicated program that subsequently confers resistance to these compounds. A mosaic of domains has been recruited to sense and metabolize these chemicals in order to obtain energy and carbon.

Publication types

  • Review

MeSH terms

  • Bacterial Proteins / metabolism
  • DNA-Binding Proteins / metabolism
  • Environmental Pollutants / metabolism*
  • Environmental Pollutants / toxicity
  • Hydrocarbons, Aromatic / metabolism
  • Hydrocarbons, Aromatic / toxicity
  • Protein Kinases / metabolism
  • Pseudomonas putida / drug effects
  • Pseudomonas putida / metabolism*
  • Signal Transduction / drug effects
  • Signal Transduction / physiology*
  • Transcription Factors / metabolism


  • Bacterial Proteins
  • DNA-Binding Proteins
  • Environmental Pollutants
  • Hydrocarbons, Aromatic
  • Transcription Factors
  • XylR protein, Pseudomonas
  • Protein Kinases
  • TodS protein, Pseudomonas putida