Cell lineages and early patterns of embryonic CNS vascularization

Cell Adh Migr. Apr-Jun 2009;3(2):205-10. doi: 10.4161/cam.3.2.7855. Epub 2009 Apr 16.

Abstract

First steps of blood vessel formation and patterning in the central nervous system (CNS) of higher vertebrates are presented. Corresponding to the regional diversity of the embryonic CNS (unsegmented spinal cord vs segmented brain anlagen) and its surroundings (segmented trunk vs unsegmented head mesoderm, neural crest-derived mesenchyme), cells of different origins contribute to the endothelial and mural cell populations. The autonomous migratory potential of endothelial cells is guided by attractive and repulsive clues. Nevertheless, a common pattern in both spinal cord and forebrain vascularization appears, with primary ventral vascular sprouts supplying the periventricular vascular plexus of the neural tube, whereas dorsolateral sprouts appear later.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Lineage*
  • Central Nervous System / blood supply
  • Central Nervous System / embryology*
  • Humans
  • Neovascularization, Pathologic*