Abstract
The specific functions of dopamine D(2) receptor-positive (D(2)R) striatopallidal neurons remain poorly understood. Using a genetic mouse model, we found that ablation of D(2)R neurons in the entire striatum induced hyperlocomotion, whereas ablation in the ventral striatum increased amphetamine conditioned place preference. Thus D(2)R striatopallidal neurons limit both locomotion and, unexpectedly, drug reinforcement.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amphetamine / pharmacology
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Animals
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Autoradiography
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Conditioning, Operant / physiology
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Corpus Striatum / cytology*
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Diphtheria Toxin / pharmacology
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Dopamine Uptake Inhibitors / pharmacology
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Enkephalins / genetics
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Enkephalins / metabolism
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Gene Expression Regulation / drug effects
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Gene Expression Regulation / genetics
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Globus Pallidus / cytology*
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Glutamate Decarboxylase / genetics
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Glutamate Decarboxylase / metabolism
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Heparin-binding EGF-like Growth Factor
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Intercellular Signaling Peptides and Proteins / genetics
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Locomotion / drug effects
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Locomotion / genetics*
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Mice
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Mice, Inbred C57BL
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Mice, Transgenic
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Nerve Tissue Proteins / metabolism
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Neurons / drug effects
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Neurons / physiology*
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Protein Binding / drug effects
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Receptors, Adenosine A2 / genetics
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Receptors, Dopamine D2 / deficiency
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Receptors, Dopamine D2 / metabolism*
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Reinforcement Schedule
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Reward*
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Time Factors
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Tyrosine 3-Monooxygenase / genetics
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Tyrosine 3-Monooxygenase / metabolism
Substances
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Diphtheria Toxin
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Dopamine Uptake Inhibitors
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Enkephalins
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Hbegf protein, mouse
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Heparin-binding EGF-like Growth Factor
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Intercellular Signaling Peptides and Proteins
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Nerve Tissue Proteins
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Receptors, Adenosine A2
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Receptors, Dopamine D2
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Amphetamine
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Tyrosine 3-Monooxygenase
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Glutamate Decarboxylase
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glutamate decarboxylase 1