Dihydrostilbene derivatives from the Mongolian medicinal plant Scorzonera radiata

J Nat Prod. 2009 Apr;72(4):671-5. doi: 10.1021/np800782f.

Abstract

Chromatographic separation of a crude extract obtained from aerial parts of the Mongolian medicinal plant Scorzonera radiata yielded five new dihydrostilbenes, scorzodihydrostilbenes A-E (1-5). The structures were unambiguously elucidated on the basis of one- and two-dimensional NMR ((1)H, (13)C, COSY, HMBC, HMQC, and ROESY) and mass spectrometric data. Compounds 1-5 exhibited antioxidative activity when analyzed in the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay. For 1 and 5 the antioxidant activities were stronger than that of the well-known naturally occurring stilbene antioxidant resveratrol.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / chemistry
  • Antioxidants / pharmacology
  • Biphenyl Compounds / pharmacology
  • Drugs, Chinese Herbal / chemistry*
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Picrates / pharmacology
  • Plants, Medicinal / chemistry
  • Resveratrol
  • Scorzonera / chemistry*
  • Stilbenes / chemistry
  • Stilbenes / isolation & purification*
  • Stilbenes / pharmacology

Substances

  • Antioxidants
  • Biphenyl Compounds
  • Drugs, Chinese Herbal
  • Picrates
  • Stilbenes
  • 1,1-diphenyl-2-picrylhydrazyl
  • Resveratrol