Antiallergic potential on RBL-2H3 cells of some phenolic constituents of Zingiber officinale (ginger)

J Nat Prod. 2009 May 22;72(5):950-3. doi: 10.1021/np800555y.


In the present study on five pure phenolic compounds (1-5) isolated from the rhizomes of Zingiber officinale (ginger) and investigated for their antiallergic potency, rat basophilic leukemia (RBL-2H3) cells were incubated with these compounds and the release of beta-hexosaminidase was measured kinetically. The data obtained suggest that ginger rhizomes harbor potent compounds capable of inhibiting allergic reactions and may be useful for the treatment and prevention of allergic diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Allergic Agents / chemistry
  • Anti-Allergic Agents / isolation & purification*
  • Anti-Allergic Agents / pharmacology*
  • Ginger / chemistry*
  • Phenols / chemistry
  • Phenols / isolation & purification*
  • Phenols / pharmacology*
  • Rats
  • Rhizome / chemistry
  • Taiwan


  • Anti-Allergic Agents
  • Phenols