PML nuclear bodies as sites of epigenetic regulation

Front Biosci (Landmark Ed). 2009 Jan 1;14(4):1325-36. doi: 10.2741/3311.


The protein-based core of a promyelocytic leukemia nuclear body (PML NB) accumulates numerous factors involved in many nuclear processes, including transcription and DNA repair. We suggest that these proteins could act on chromatin in the vicinity of the bodies. The physical dependence of PML NB structure on the integrity of the surrounding DNA implies a functional connection between the bodies and chromatin. Indeed, some genetic loci are non-randomly associated with PML NBs, indicating that nuclear bodies organize at specific loci, or are able to recruit specific genetic loci to their periphery. Since many of the factors that accumulate in PML NBs and PML-containing structures in acute promyelocytic leukemia cells are known histone methyltransferases, histone deacetylases or DNA methyltransferases, we suggest that PML NBs may have a role as epigenetic regulators. Down-regulation of normal PML protein, observed in a variety of cancers, may impair epigenetic regulation in early tumorigenesis, which ultimately leads to genetic instability and cellular transformation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Nucleus / metabolism*
  • Chromatin / metabolism
  • Epigenesis, Genetic*
  • Genome, Human
  • Humans
  • Nuclear Proteins / chemistry
  • Nuclear Proteins / genetics*
  • Nuclear Proteins / metabolism
  • Promyelocytic Leukemia Protein
  • Protein Conformation
  • Transcription Factors / chemistry
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism
  • Tumor Suppressor Proteins / chemistry
  • Tumor Suppressor Proteins / genetics*
  • Tumor Suppressor Proteins / metabolism


  • Chromatin
  • Nuclear Proteins
  • Promyelocytic Leukemia Protein
  • Transcription Factors
  • Tumor Suppressor Proteins
  • PML protein, human