Ovarian cancer: pathology, biology, and disease models

Front Biosci (Landmark Ed). 2009 Jan 1;14:2089-102. doi: 10.2741/3364.

Abstract

Epithelial ovarian cancer, which comprises several histologic types and grades, is the most lethal cancer among women in the United States. In this review, we summarize recent progress in understanding the pathology and biology of this disease and in development of models for preclinical research. Our new understanding of this disease suggests new targets for therapeutic intervention and novel markers for early detection of disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Female
  • Genes, Homeobox
  • Humans
  • Ovarian Neoplasms / classification
  • Ovarian Neoplasms / genetics
  • Ovarian Neoplasms / pathology*