Role of phosphoinositide 3-kinases in regulating cardiac function

Front Biosci (Landmark Ed). 2009 Jan 1;14:2221-9. doi: 10.2741/3374.

Abstract

Phosphoinositide 3-kinases (PI3Ks) are important signaling proteins in the heart. Class IA PI3Ks (p110alpha, beta) are critical regulators of physiological heart growth and cell survival, and are generally considered to be beneficial for heart function. In contrast, activation of class IB PI3K(p110gamma) is detrimental for heart function, reducing cardiac contractility. This may have implications for the treatment of heart disease and failure. In vitro, ex vivo and in vivo studies have contributed to our understanding of PI3K signaling in the heart. This review summarizes class I PI3K signaling in the regulation of cardiac function, with a particular focus on the role of different PI3K isoforms in settings of heart disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Heart / physiology*
  • Heart Failure / enzymology
  • Humans
  • Myocardium / enzymology*
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Signal Transduction

Substances

  • Phosphatidylinositol 3-Kinases