Glaucoma monitoring in a clinical setting: glaucoma progression analysis vs nonparametric progression analysis in the Groningen Longitudinal Glaucoma Study

Arch Ophthalmol. 2009 Mar;127(3):270-4. doi: 10.1001/archophthalmol.2008.585.


Objective: To compare prospectively 2 perimetric progression detection algorithms for glaucoma, the Early Manifest Glaucoma Trial algorithm (glaucoma progression analysis [GPA]) and a nonparametric algorithm applied to the mean deviation (MD) (nonparametric progression analysis [NPA]).

Methods: Patients with a reproducible glaucomatous visual field defect at baseline in at least 1 eye were followed up prospectively using perimetry (Humphrey field analyzer 30-2 Swedish interactive thresholding algorithm). Classifications by GPA and by NPA at the end of the follow-up period were compared.

Results: Two hundred twenty-one patients met the inclusion criteria; 1 eye per patient was analyzed. On average, 7.1 reliable fields were available after a mean follow-up period of 5.3 years. The mean MD at baseline was -9.4 dB; the mean MD slope during the follow-up period was -0.25 dB/y. Fifty-six eyes showed progression by GPA and 89 eyes by NPA (P < .001); 42 eyes showed progression by both techniques (kappa = 0.39). In eyes with progression detected by NPA only, baseline MD was worse than that in eyes with progression detected by GPA (-12.5 vs -8.2 dB, P = .002), and GPA more often gave a reading of "baseline MD out of range" (P < .001). After exclusion of eyes with baseline MD out of range, the measure of agreement was kappa = 0.50.

Conclusions: Nonparametric progression analysis had fairly good agreement with GPA. Especially in cases of more advanced disease, NPA labeled more eyes as having progression than GPA.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Algorithms*
  • Axons / pathology
  • Female
  • Glaucoma / diagnosis*
  • Glaucoma / physiopathology*
  • Humans
  • Longitudinal Studies
  • Male
  • Prospective Studies
  • Retinal Ganglion Cells / pathology
  • Statistics, Nonparametric*
  • Vision Disorders / diagnosis
  • Vision Disorders / physiopathology
  • Visual Field Tests / methods
  • Visual Fields