Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Apr;10(4):252-63.
doi: 10.1038/nrg2538.

A Census of Human Transcription Factors: Function, Expression and Evolution

Affiliations
Review

A Census of Human Transcription Factors: Function, Expression and Evolution

Juan M Vaquerizas et al. Nat Rev Genet. .

Abstract

Transcription factors are key cellular components that control gene expression: their activities determine how cells function and respond to the environment. Currently, there is great interest in research into human transcriptional regulation. However, surprisingly little is known about these regulators themselves. For example, how many transcription factors does the human genome contain? How are they expressed in different tissues? Are they evolutionarily conserved? Here, we present an analysis of 1,391 manually curated sequence-specific DNA-binding transcription factors, their functions, genomic organization and evolutionary conservation. Much remains to be explored, but this study provides a solid foundation for future investigations to elucidate regulatory mechanisms underlying diverse mammalian biological processes.

Similar articles

See all similar articles

Cited by 602 articles

See all "Cited by" articles

References

    1. Cell. 2001 Sep 21;106(6):697-708 - PubMed
    1. Nature. 2007 Feb 22;445(7130):936-40 - PubMed
    1. Nat Rev Genet. 2008 Nov;9(11):868-82 - PubMed
    1. Cell Regul. 1991 Jul;2(7):575-88 - PubMed
    1. Genome Biol. 2005;6(13):R110 - PubMed

Publication types

Substances

LinkOut - more resources

Feedback