Preserved residual renal function is associated with lower oxidative stress in peritoneal dialysis patients

Nephrol Dial Transplant. 2009 May;24(5):1685-9. doi: 10.1093/ndt/gfp077. Epub 2009 Mar 9.


Background: Residual renal function (RRF) correlates with survival in peritoneal dialysis (PD). We investigated the association between oxidative stress and RRF in PD.

Methods: Adequacy of dialysis, total and free malondialdehydes (MDA), and lipid hydroperoxides (LHP) were obtained from 23 stable PD patients.

Results: Free MDA level decreased with total weekly Kt/V urea (r = -0.51, P = 0.013) and urinary Kt/V (KRU) (r = -0.53, P = 0.009), but not with peritoneal Kt/V. Similar results were found with LHP level. In multivariate analysis, total weekly Kt/V urea and KRU remained associated with free MDA and LHP, independently of gender, nutritional or inflammatory status, and peritoneal permeability.

Conclusion: A preserved RRF is associated with lower serum levels of lipid peroxidation products among PD patients.

MeSH terms

  • Adult
  • Aged
  • Cross-Sectional Studies
  • Female
  • Humans
  • Kidney / physiology*
  • Kidney Diseases / physiopathology*
  • Kidney Diseases / therapy*
  • Lipid Peroxidation / physiology
  • Lipid Peroxides / blood
  • Male
  • Malondialdehyde / blood
  • Middle Aged
  • Multivariate Analysis
  • Oxidative Stress / physiology*
  • Peritoneal Dialysis*


  • Lipid Peroxides
  • Malondialdehyde