Migraine in metabolic syndrome

Neurologist. 2009 Mar;15(2):55-8. doi: 10.1097/NRL.0b013e31817781b6.


Objectives: Recent studies suggest that insulin resistance is more common in patients with migraine. Insulin resistance underlies the pathogenesis of obesity, diabetes, and hypertension that are components of metabolic syndrome. As migraine is associated with an increased risk of vascular disorders, such as stroke, and migraine patients have higher diastolic blood pressure than healthy individuals, we aimed to investigate the 1-year prevalence of migraine in metabolic syndrome.

Methods: Two hundred ten patients with metabolic syndrome were enrolled in the study. Migraine was diagnosed according to International Classification of Headache Disorders-II criteria.

Results: Migraine prevalence was estimated as 11.9% in men and 22.5% in women with metabolic syndrome. Of the metabolic syndrome components, diabetes, increased waist circumference, and body mass index were significantly more frequent in patients with migraine in contrast to those without migraine (P<0.05). Hypertension and dyslipidemia frequencies showed no difference between 2 groups.

Conclusions: Our results demonstrate that migraine prevalence in metabolic syndrome was higher than in the general population.

MeSH terms

  • Adult
  • Aged
  • Female
  • Humans
  • Male
  • Metabolic Syndrome / epidemiology*
  • Middle Aged
  • Migraine Disorders / epidemiology*
  • Prevalence
  • Sex Factors
  • Young Adult