Recombinant bone morphogenic protein-2 in orthopaedic surgery: a review

Arch Orthop Trauma Surg. 2009 Dec;129(12):1651-7. doi: 10.1007/s00402-009-0850-8. Epub 2009 Mar 12.


Bone morphogenic proteins (BMPs) are pleiotropic regulators of bone volume, skeletal organogenesis and bone regeneration after a fracture. They function as signaling agents to affect cellular events like proliferation, differentiation and extracellular matrix synthesis. Clinically utilized rhBMP-2 combines rhBMP-2 with an osteoconductive carrier to induce bone growth and acts as a bone graft substitute. rhBMP-2, initially released in 2002, has been used primarily in spinal fusions in the lumbar and cervical regions. Recently, the application of rhBMP-2 has extended into the orthopedic trauma setting with increased application in open tibia fractures. This review outlines the history of development, molecular characteristics, toxicity and clinical applications.

Publication types

  • Review

MeSH terms

  • Animals
  • Bone Morphogenetic Protein 2 / therapeutic use*
  • Fractures, Malunited / therapy
  • Humans
  • Orthopedic Procedures*
  • Recombinant Proteins / therapeutic use*
  • Spinal Fusion


  • Bone Morphogenetic Protein 2
  • Recombinant Proteins