Association between the use of non-antiarrhythmic drugs and postoperative atrial fibrillation

Mehmet Ozaydin; Yasin Turker; Oktay Peker; Dogan Erdogan; Ercan Varol; Abdullah Dogan; Erdogan Ibrisim

doi:10.1016/j.ijcard.2009.02.029

Association between the use of non-antiarrhythmic drugs and postoperative atrial fibrillation

Int J Cardiol. 2010 Oct 8;144(2):304-6. doi: 10.1016/j.ijcard.2009.02.029. Epub 2009 Mar 17.

Authors

Mehmet Ozaydin, Yasin Turker, Oktay Peker, Dogan Erdogan, Ercan Varol, Abdullah Dogan, Erdogan Ibrisim

PMID: 19282043
DOI: 10.1016/j.ijcard.2009.02.029

Abstract

Purpose: To evaluate the association between statins, N-acetylcysteine (NAC) and angiotensin converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) and postoperative atrial fibrillation (AF).

Methods: A total of 590 patients undergoing coronary artery bypass and/or valve surgery were studied. An AF episode lasting >5 min during hospitalization was accepted as endpoint.

Results: AF rate was 18% (n=106). Multivariable positive predictors of AF included age ≥ 65, left atrial diameter ≥ 45 mm, cross clamp time; negative predictors included use of left internal mammarian artery, NAC, and ACEIs or ARBs.

Conclusions: ACEIs or ARBs and NAC is associated with low incidence of postoperative AF, however, this association was not found with statin or combined use these agents.

Publication types

Letter

MeSH terms

Acetylcysteine / therapeutic use
Angiotensin Receptor Antagonists / therapeutic use
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Atrial Fibrillation / drug therapy*
Atrial Fibrillation / etiology*
Cardiac Surgical Procedures / adverse effects*
Female
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
Male
Middle Aged

Substances

Angiotensin Receptor Antagonists
Angiotensin-Converting Enzyme Inhibitors
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Acetylcysteine