Association between the use of non-antiarrhythmic drugs and postoperative atrial fibrillation

Int J Cardiol. 2010 Oct 8;144(2):304-6. doi: 10.1016/j.ijcard.2009.02.029. Epub 2009 Mar 17.

Abstract

Purpose: To evaluate the association between statins, N-acetylcysteine (NAC) and angiotensin converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) and postoperative atrial fibrillation (AF).

Methods: A total of 590 patients undergoing coronary artery bypass and/or valve surgery were studied. An AF episode lasting >5 min during hospitalization was accepted as endpoint.

Results: AF rate was 18% (n=106). Multivariable positive predictors of AF included age ≥ 65, left atrial diameter ≥ 45 mm, cross clamp time; negative predictors included use of left internal mammarian artery, NAC, and ACEIs or ARBs.

Conclusions: ACEIs or ARBs and NAC is associated with low incidence of postoperative AF, however, this association was not found with statin or combined use these agents.

Publication types

  • Letter

MeSH terms

  • Acetylcysteine / therapeutic use
  • Angiotensin Receptor Antagonists / therapeutic use
  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use
  • Atrial Fibrillation / drug therapy*
  • Atrial Fibrillation / etiology*
  • Cardiac Surgical Procedures / adverse effects*
  • Female
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
  • Male
  • Middle Aged

Substances

  • Angiotensin Receptor Antagonists
  • Angiotensin-Converting Enzyme Inhibitors
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Acetylcysteine