Intravenous fat emulsion therapy for intentional sustained-release verapamil overdose

Resuscitation. 2009 May;80(5):591-3. doi: 10.1016/j.resuscitation.2009.01.023. Epub 2009 Mar 17.

Abstract

We report the first case of sustained-release verapamil toxicity treated with Intralipid fat emulsion (IFE). Toxicity was confirmed by elevated serial serum verapamil and metabolite, norverapamil, levels. Most previously reported cases of IFE therapy involve local anaesthetic toxicity and cardiac arrest. Our patient was in shock despite standard therapy. No adverse events were noted and the patient fully recovered.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Bradycardia / chemically induced
  • Bradycardia / diagnosis
  • Bradycardia / drug therapy
  • Calcium Channel Blockers / administration & dosage
  • Calcium Channel Blockers / blood
  • Calcium Channel Blockers / poisoning*
  • Delayed-Action Preparations
  • Drug Overdose / therapy
  • Electrocardiography
  • Fat Emulsions, Intravenous / therapeutic use*
  • Humans
  • Male
  • Verapamil / administration & dosage
  • Verapamil / analogs & derivatives
  • Verapamil / blood
  • Verapamil / poisoning*

Substances

  • Calcium Channel Blockers
  • Delayed-Action Preparations
  • Fat Emulsions, Intravenous
  • norverapamil
  • Verapamil