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Review
. 2009 Apr;30(4):157-64.
doi: 10.1016/j.it.2009.01.005. Epub 2009 Mar 11.

Germinal Centres Seen Through the Mathematical Eye: B-cell Models on the Catwalk

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Review

Germinal Centres Seen Through the Mathematical Eye: B-cell Models on the Catwalk

Michael Meyer-Hermann et al. Trends Immunol. .

Abstract

Germinal centres are receiving renewed attention following recent intravital multi-photon imaging studies. These data have shed new light on longstanding questions about the spatial organisation of germinal centres, B-cell migration, selection and differentiation. Mathematical models have proven invaluable in the analysis of intravital motility data, and have predicted novel B-cell selection mechanisms that are now supported by experimental findings. We argue that mathematical modelling adds a different vantage point to experimental data and provides a quantitative and systematic analysis of hypotheses and theories in immunology. Furthermore, the well-characterised nature of the germinal centre provides an excellent proving ground for mathematical modelling.

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