The role of the matrix metalloproteinase stromelysin in the progression of squamous cell carcinomas

Am J Med Sci. 1991 Sep;302(3):157-62. doi: 10.1097/00000441-199109000-00008.


The expression of the metalloproteinase stromelysin correlates with the progression of chemically induced squamous cell carcinomas. We demonstrate that the expression of activated stromelysin in papilloma-derived cells enhances in vitro cell invasion. We also demonstrate that the Ha-ras oncogene induces the transcription of the stromelysin gene through an AP-1 dependent pathway. The hypothesis is that alterations in oncogenes and suppressor genes influence stromelysin expression and thus influence subsequent steps of tumor invasion and metastasis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Carcinoma, Squamous Cell / pathology*
  • Gene Expression Regulation, Enzymologic
  • Genes, ras
  • Humans
  • Matrix Metalloproteinase 3
  • Metalloendopeptidases / genetics
  • Metalloendopeptidases / physiology*
  • Neoplasm Invasiveness*
  • Transforming Growth Factor beta / pharmacology


  • Transforming Growth Factor beta
  • Metalloendopeptidases
  • Matrix Metalloproteinase 3