Reported success rates for decompressing the radial nerve in patients with radial tunnel syndrome vary between 10 and 95%. The combined treatment, releasing both the posterior interosseous nerve and the superficial branch of the radial nerve, has been described only three times, but seems to show more consistent success rates compared with releasing the posterior interosseous nerve alone. We present the results of decompressing the superficial branch of the radial nerve only, the anatomical basis for this approach and a description of the surgical technique. Our results are comparable to the results of the combined treatment. Eleven of 12 patients were satisfied with the results of the operation. This study indicates that pain in patients with radial tunnel syndrome may be treated successfully by surgical decompression of the superficial branch of the radial nerve.