Chipping Away at Diagnostics for Neurodegenerative Diseases

Neurobiol Dis. 2009 Aug;35(2):148-56. doi: 10.1016/j.nbd.2009.02.016. Epub 2009 Mar 10.

Abstract

Biomarkers are needed to overcome critical roadblocks in the development of disease-modifying therapeutics for neurodegenerative diseases. Evolving genome-wide expression technologies can comprehensively search for molecular biomarkers and allow fascinating insights into the expanding complexity of the human transcriptome. The technology has matured to the point where some applications are deemed reliable enough for use in patient care. In the neurosciences, it has led to the discoveries of osteopontin in multiple sclerosis and SORL1/LR11 in Alzheimer's, and recent studies indicate its potential for identifying neurogenomic biomarkers. Advances in pre-analytical and analytical methods are improving search efficiency and reproducibility and may lead to a pipeline of biomarker candidates suitable for development into future neurologic diagnostics.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Alzheimer Disease / genetics
  • Alzheimer Disease / metabolism
  • Animals
  • Biomarkers / metabolism
  • Brain / metabolism
  • Clinical Trials as Topic
  • Gene Expression*
  • Genetic Predisposition to Disease
  • Humans
  • LDL-Receptor Related Proteins / genetics
  • LDL-Receptor Related Proteins / metabolism
  • Membrane Transport Proteins / genetics
  • Membrane Transport Proteins / metabolism
  • Multiple Sclerosis / genetics
  • Multiple Sclerosis / metabolism
  • Neurodegenerative Diseases / diagnosis*
  • Neurodegenerative Diseases / genetics*
  • Neurodegenerative Diseases / metabolism
  • Oligonucleotide Array Sequence Analysis / methods
  • Osteopontin / genetics
  • Osteopontin / metabolism
  • RNA / metabolism

Substances

  • Biomarkers
  • LDL-Receptor Related Proteins
  • Membrane Transport Proteins
  • SORL1 protein, human
  • Osteopontin
  • RNA