Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting

Nat Genet. 2009 Apr;41(4):396-8. doi: 10.1038/ng.321. Epub 2009 Mar 15.


Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Substitution
  • Animals
  • Binding Sites
  • Calcium / metabolism
  • Cell Division
  • Cell Movement
  • Embryo, Nonmammalian / physiology
  • Embryonic Development
  • Epidermal Growth Factor / genetics*
  • Humans
  • Lymphangiogenesis / genetics*
  • Lymphatic Vessels / cytology
  • Lymphatic Vessels / embryology
  • Lymphatic Vessels / physiology*
  • Models, Animal
  • Mutation*
  • Vascular Endothelial Growth Factor C / genetics
  • Zebrafish


  • VEGFC protein, human
  • Vascular Endothelial Growth Factor C
  • Epidermal Growth Factor
  • Calcium