Pulmonary arterial hypertension and thyroid disease

J Bras Pneumol. 2009 Feb;35(2):179-85. doi: 10.1590/s1806-37132009000200012.


Recent studies have suggested an association between pulmonary arterial hypertension (PAH) and thyroid diseases (hypothyroidism and hyperthyroidism). This combination has a good prognosis, because the increase in the pulmonary artery pressure is usually slight and reverses after the treatment of the thyroid disease. Although the exact mechanism involved in the pathogenesis of this combination has not yet been established, it has been hypothesized that thyroid hormones and autoimmunity have a direct influence. Due to the high prevalence of thyroid disease in patients with PAH, thyroid function tests should be considered in the investigation of every patient with PAH. In this review, we describe the prevalence of PAH in patients with thyroid diseases and the prevalence of thyroid disease in patients with PAH, as well as addressing the principal effects that thyroid diseases have on the respiratory system. In addition, we report the treatment effects in patients with these diseases.

Publication types

  • Review

MeSH terms

  • Graves Disease / complications
  • Graves Disease / epidemiology
  • Humans
  • Hypertension, Pulmonary / complications*
  • Hypertension, Pulmonary / epidemiology
  • Hypertension, Pulmonary / therapy
  • Hyperthyroidism / complications*
  • Hyperthyroidism / epidemiology
  • Hypothyroidism / complications*
  • Hypothyroidism / epidemiology
  • Pulmonary Artery
  • Thyroid Hormones


  • Thyroid Hormones