Effect of a low dose of sea buckthorn berries on circulating concentrations of cholesterol, triacylglycerols, and flavonols in healthy adults

Eur J Nutr. 2009 Aug;48(5):277-82. doi: 10.1007/s00394-009-0011-4. Epub 2009 Mar 14.


Background: Epidemiological studies indicate beneficial effects of flavonoids on cardiovascular disease (CVD) risk.

Aim of the study: To study the effect of flavonoid-rich sea buckthorn berry (SBB) on circulating lipid markers associated with CVD risk and plasma flavonol concentration. Also investigated was whether changes in the circulating flavonol concentrations correlate with the SBB induced changes in C-reactive protein (CRP) concentration observed previously.

Subjects and methods: In all 229 healthy participants completed the randomized double-blind study and consumed daily 28 g of SBB or placebo for 3 months. Fasting blood samples for the analysis of lipid markers and flavonols were obtained at the beginning and end of the study.

Results: Compared to the placebo, the consumption of SBB increased the plasma concentration of the flavonols quercetin and isorhamnetin significantly [treatment differences 3.0 ng/ml (P = 0.03) and 3.9 ng/ml (P < 0.01), respectively]. The increase of kaempferol concentration was not significant [treatment difference 0.7 ng/ml (P = 0.08)]. SBB did not affect the serum total, HDL, LDL cholesterol, or the serum triacylglycerol concentrations. There was no correlation between the changes in flavonol and CRP concentrations of participants.

Conclusions: The consumption of SBB significantly increased the fasting plasma concentration of quercetin and isorhamnetin indicating that it is a good dietary source of flavonols. However, this did not convert to affecting the circulating concentrations of lipid markers in healthy, normolipidemic adults having healthy diets.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • C-Reactive Protein / analysis
  • C-Reactive Protein / metabolism
  • Cardiovascular Diseases / blood
  • Cardiovascular Diseases / epidemiology
  • Cardiovascular Diseases / prevention & control
  • Cholesterol / blood*
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Female
  • Flavonols / blood*
  • Fruit*
  • Hippophae / chemistry*
  • Humans
  • Male
  • Middle Aged
  • Quercetin / blood
  • Triglycerides / blood*
  • Young Adult


  • Flavonols
  • Triglycerides
  • 3-methylquercetin
  • C-Reactive Protein
  • Cholesterol
  • Quercetin