Rigidity-dependent cross talk between integrin and cadherin signaling

Biophys J. 2009 Mar 18;96(6):L39-41. doi: 10.1016/j.bpj.2009.01.005.


Integrin-cadherin cross talk is an important aspect of cell function. We explored this signaling using substrates micropatterned with islands of fibronectin surrounded by E-cadherin, capturing the segregation of these signals in normal tissue. While MDCK cells were able to concurrently form adhesive structures with these two proteins, engagement of fibronectin by MCF-7 cells, an adenocarcinoma cell line, inhibited response of these cells to E-cadherin. We further demonstrated that this inhibition is rigidity dependent; on soft elastomer substrates with Young's modulus in the range of tens of kiloPascals, MCF-7 cells were able to engage both integrin and cadherin ligands.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Cadherins / metabolism*
  • Cell Adhesion / physiology
  • Cell Line
  • Cell Line, Tumor
  • Dogs
  • Elasticity*
  • Epithelial Cells / metabolism
  • Fibronectins / metabolism
  • Humans
  • Integrins / metabolism*
  • Signal Transduction*
  • src-Family Kinases / metabolism


  • Cadherins
  • Fibronectins
  • Integrins
  • src-Family Kinases