Abstract
Clustering of acetylcholine receptors (AChR) in muscle fibers prior to innervation by motor neurons is thought to be involved in neuromuscular junction formation. Jing et al. now report in Neuron that this prepatterning of AChRs, via a novel MuSK-dependent Wnt pathway, may guide motor axons to the central region of muscle fibers for synapse formation in zebrafish.
MeSH terms
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Animals
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Body Patterning / genetics
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Body Patterning / physiology
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Humans
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Mammals
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Models, Neurological
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Mutation
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Neuromuscular Junction / growth & development*
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Receptor Protein-Tyrosine Kinases / genetics
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Receptor Protein-Tyrosine Kinases / physiology
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Receptors, Cholinergic / physiology
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Receptors, LDL / genetics
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Receptors, LDL / physiology
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Wnt Proteins / genetics
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Wnt Proteins / physiology*
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Zebrafish
Substances
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Receptors, Cholinergic
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Receptors, LDL
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Wnt Proteins
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Receptor Protein-Tyrosine Kinases