Thoracoscopic talc poudrage pleurodesis for chronic recurrent pleural effusions

Ann Intern Med. 1991 Nov 15;115(10):778-82. doi: 10.7326/0003-4819-115-10-778.


Objective: To assess the effectiveness of thoracoscopic talc poudrage for the treatment of chronic pleural effusions.

Design: Prospective evaluation.

Setting: Kaiser-Permanente Hospital.

Patients: Forty-seven consecutive patients with recalcitrant pleural effusions, referred for thoracoscopy.

Intervention: Patients received general or local anesthesia; 42 had a 7-mm rigid thoracoscopic examination followed by insufflation of 5 mL of talc. Patients then had chest-tube drainage.

Measurements: We recorded clinical characteristics, final diagnosis, procedure-related pain and morbidity, days of hospitalization, patient-reported degree of symptom relief, and chest roentgenographic results at 1, 3, and 12 months. All patients were followed for 16 months or until death.

Main results: Of 39 evaluable patients, all reported prolonged relief of effusion-related dyspnea. Radiographic results confirmed the elimination of pleural effusions in 34 patients (87%), including all 11 with benign conditions and 23 of 28 (82%) with malignancies. Treatment failed in three patients because of entrapped lung and in two patients with mesotheliomas whose effusions recurred more than a year after treatment. No procedure-related mortality or morbidity was found. Ambulatory patients required hospitalization for a mean of 3.9 days (range, 2 to 11 days). Mild pain was reported by some patients. The mean duration of chest-tube drainage was 2.7 days (range, 1 to 9 days). Patients with malignant disease lived an average of 12.4 months (range, 1 to 61 months) after the procedure.

Conclusions: Thoracoscopic talc poudrage is an effective pleural sclerosing technique and is relatively painless.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Chronic Disease
  • Evaluation Studies as Topic
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Pleural Effusion / therapy*
  • Recurrence
  • Sclerosing Solutions / therapeutic use
  • Sclerotherapy / methods*
  • Survival Rate
  • Talc / therapeutic use*
  • Thoracoscopy


  • Sclerosing Solutions
  • Talc