Rac and Rho driving tumor invasion: who's at the wheel?

Genome Biol. 2009;10(3):213. doi: 10.1186/gb-2009-10-3-213. Epub 2009 Mar 6.

Abstract

Genome-wide analysis of regulators of Rho-family small GTPases has identified critical elements that control the morphology and invasive behavior of melanoma cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Shape
  • Humans
  • Neoplasm Invasiveness / pathology*
  • Phenotype
  • rac GTP-Binding Proteins / metabolism*
  • rho GTP-Binding Proteins / metabolism*

Substances

  • rac GTP-Binding Proteins
  • rho GTP-Binding Proteins