The transition from ductal carcinoma in situ to invasive breast cancer: the other side of the coin

Breast Cancer Res. 2009;11(1):101. doi: 10.1186/bcr2228. Epub 2009 Feb 27.


The factors associated with the progression of ductal carcinoma in situ (DCIS) to invasive breast cancer are poorly understood. Many studies of this subject focus on the role of molecular and genetic alterations in the neoplastic epithelial cells. However, emerging evidence suggests that transition from DCIS to invasive cancer is strongly dependent upon alterations in the microenvironment. The potential roles of myoepithelial cells and of stromal-epithelial interaction are of particular interest in this regard.

Publication types

  • Comment
  • Editorial

MeSH terms

  • Breast Neoplasms / pathology*
  • Carcinoma, Intraductal, Noninfiltrating / pathology*
  • Epithelial Cells / pathology*
  • Female
  • Humans
  • Neoplasm Invasiveness / pathology*