Abstract
Interstitial cystitis causes disabling bladder pain and is usually diagnosed in the absence of infection. We describe a patient with interstitial cystitis who had high urinary levels of polyomavirus that decreased dramatically after initiation of intravesical cidofovir treatment; the patient also showed substantial improvement in symptoms. Another patient had milder symptoms of cystitis and intermittent polyomavirus shedding. Polyomaviruses, particularly BK virus, may cause some cases of interstitial cystitis.
MeSH terms
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Administration, Intravesical
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Antiviral Agents / administration & dosage
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Antiviral Agents / therapeutic use*
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Cidofovir
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Cystitis, Interstitial / drug therapy
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Cystitis, Interstitial / physiopathology*
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Cystitis, Interstitial / virology
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Cytosine / administration & dosage
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Cytosine / analogs & derivatives*
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Cytosine / therapeutic use
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Female
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Humans
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Male
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Middle Aged
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Organophosphonates / administration & dosage
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Organophosphonates / therapeutic use*
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Polyomavirus / isolation & purification*
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Polyomavirus Infections / drug therapy
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Polyomavirus Infections / physiopathology*
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Polyomavirus Infections / virology
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Urine / virology*
Substances
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Antiviral Agents
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Organophosphonates
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Cytosine
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Cidofovir