Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras

Biochem Biophys Res Commun. 2009 May 8;382(3):561-5. doi: 10.1016/j.bbrc.2009.03.068. Epub 2009 Mar 16.


Chronic pancreatitis increases by 16-fold the risk of developing pancreatic ductal adenocarcinoma (PDAC), one of the deadliest human cancers. It also appears to accelerate cancer progression in genetically engineered mouse models. We now report that in a mouse model where oncogenic Kras is activated in all pancreatic cell types, two brief episodes of acute pancreatitis caused rapid PanIN progression and accelerated pancreatic cancer development. Thus, a brief inflammatory insult to the pancreas, when occurring in the context of oncogenic Kras(G12D), can initiate a cascade of events that dramatically enhances the risk for pancreatic malignant transformation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic / metabolism*
  • Cell Transformation, Neoplastic / pathology*
  • Disease Models, Animal
  • Disease Progression
  • Mice
  • Mice, Inbred Strains
  • Pancreatic Neoplasms / etiology*
  • Pancreatic Neoplasms / metabolism
  • Pancreatic Neoplasms / pathology*
  • Pancreatitis / complications*
  • Pancreatitis / metabolism
  • Pancreatitis / pathology
  • Proto-Oncogene Proteins p21(ras) / biosynthesis*
  • Proto-Oncogene Proteins p21(ras) / genetics


  • Hras protein, mouse
  • Proto-Oncogene Proteins p21(ras)