Oxovanadium(IV)-based near-IR PDT agents: design to biological evaluation

Pijus K Sasmal; Sounik Saha; Ritankar Majumdar; Rajan R Dighe; Akhil R Chakravarty

doi:10.1039/b822229k

Oxovanadium(IV)-based near-IR PDT agents: design to biological evaluation

Chem Commun (Camb). 2009 Apr 7:(13):1703-5. doi: 10.1039/b822229k. Epub 2009 Feb 16.

Authors

Pijus K Sasmal¹, Sounik Saha, Ritankar Majumdar, Rajan R Dighe, Akhil R Chakravarty

Affiliation

¹ Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore, 560012, India.

PMID: 19294268
DOI: 10.1039/b822229k

Abstract

An oxovanadium(IV) complex of dipyridophenazine, as a potent metal-based PDT agent, shows efficient DNA photocleavage activity at near-IR region and high photocytotoxicity in both UV-A and visible light in HeLa cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Drug Design
Electrophoresis, Polyacrylamide Gel
HeLa Cells
Humans
Photochemotherapy*
Spectroscopy, Near-Infrared / methods*
Vanadium / chemistry*

Substances

Vanadium